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In contrast, senomorphics work by modulating the SASP or altering the cellular environment to alleviate the negative effects of senescence without eliminating the senescent cells themselves.5 Both approaches offer a unique opportunity to delay the onset of age-related diseases and extend the healthspan, the period of life spent in good health
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However, upon deletion of PNPLA2 from WAT and BAT, mice were cold sensitive under fasting conditions, suggesting that WAT-derived FAs additionally function to support BAT thermogenesis (102)
