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Clinical evidence: The SURMOUNT-1 trial, published in the New England Journal of Medicine , showed that participants on the highest dose of tirzepatide (15 mg) lost an average of 22.5 percent of their body weight over 72 weeks the most weight loss ever demonstrated by a pharmaceutical agent in a clinical trial (Jastreboff et al., 2022)

Such deficiencies are caused by several factors, including pernicious anemia, which constitutes a minority of cases, poor dietary intake, or food-bound cobalamin malabsorption (FBCM) (, )

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