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Lastly, phosphoserine phosphatase induces the hydrolysis of 3-PS, leading to the production of serine ( 3-PG is synthesized during glycolysis or gluconeogenesis ( Serine metabolism has emerged as a crucial participant in cancer biology, and PHGDH, the rate-limiting enzyme of de novo serine biosynthesis has garnered attention as a therapeutic target ( Dysregulated translation is a hallmark of cancer cells, enabling them to sustain uncontrolled growth and proliferation ( Our transcriptomic analysis revealed significant alterations in several pathways following the treatment of Rylaze in AML