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Under stress, Nrf2 becomes unstable, translocates to the nucleus, binds to the antioxidant response element (ARE) in the promoter region, and regulates lipid peroxidation while promoting the transcription of the ferroptosis-related gene SLC7 A11 [21]

However, markedly elevated levels without supplementation may warrant GP review to exclude underlying conditions such as haematological disorders, liver disease, or renal impairment

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