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One possibility is that the cell cycle organizes hyperstructures so as to yield two different coherent phenotypes, one (containing non-equilibrium hyperstructures) suitable for growth and the other (containing equilibrium hyperstructures) suitable for survival (Norris, 2015)
Letrozole + ribociclib versus letrozole + placebo as neoadjuvant therapy for ER+ breast cancer (FELINE trial)

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The average dose ranges between 200mcg and 300mcg per day
