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The attack increases the BBBs permeability, allowing immune cells and plasma proteins to enter the brain parenchyma, worsening the inflammatory process [72]

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This synthesis is driven by two enzymatic reactions: Glutamate-Cysteine Ligase (GCL) and Glutathione Synthetase(GSS).GCL catalyzes the binding of glutamate to cysteine, while GSS facilitates the attachment of glycine to glutamylcysteine, forming GSH

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