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Nazrolu M, Kutluhan S, Ylmaz M (2008) Selenium and Topiramate modulates brain microsomal oxidative stress values, Ca2+-ATPase activity, and EEG records in Pentylentetrazol-Induced seizures in rats

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Furthermore, future research should prioritize large-scale, long-term randomized controlled trials to definitively establish optimal dosing regimens, confirm sustained efficacy across diverse PCOS phenotypesespecially considering inherent heterogeneity and ethnic variations, and rigorously evaluate hard clinical endpoints such as live birth rates, prevention of T2D/cardiovascular events, and endometrial cancer risk reduction