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Description
Essentially, upon activation, mTORC1 initiates the phosphorylation of eukaryotic initiation factor 4E binding protein 1 (4EBP1) and ribosomal protein S6 kinase 1 (Dong et al., 2018)
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The concept initially consisted of using a lateral margin proportional to the largest tumor diameter, for tumors below 4 cm, and a fixed margin of 4 cm for tumors above this diameter, maintaining a deep margin of at least one fascial plane [150]
10.1111/j.1524-4733.2008.00436.x Value Health
