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In summary, the impairment of System Xc - function significantly enhances ferroptosis sensitivity in drug-resistant cancers, offering a promising therapeutic target for overcoming chemoresistance.Notably, certain drug-resistant cancer cells can counteract System Xc- inhibition by activating alternative cysteine acquisition pathways, such as the transsulfuration pathway mediated by cystathionine -synthase (CBS) or direct cysteine uptake via ASCT transporters (52)

doi: 10.1016/S0002-9343(98)00179-X 358 KuratsuneHYamagutiKLindhGEvengrdBHagbergGMatsumuraKet al

BPC-157 and TB-500 Blend This is a blend (10mg) each of BPC-157 (5mg) and TB-500 (5mg)

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