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However, in addition to their ability to directly interact with biological molecules (lipids, proteins or nucleic acids), ROS damage also involves the alteration of signaling pathways, such as activation of the NF- pathway, which in turn activates the gene expression of several pro-inflammatory cytokines [16,19,26]

Environ Toxicol Chem 17:161165 Hunter D (1978) Diseases of occupations, 6th edn

Chronic illness, oxidative stress, and medications deplete glutathione and may require higher replacement doses

Freeze-thawed liposomes involve quick freezing and gradual thawing of SUVs followed by sonication of the aggregates which disperses them resulting in the formation of LUVs [144]