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Description
Retatrutide : This triple agonist (GLP-1 + GIP + glucagon) produced 28.7% weight loss in Phase 3 but introduced a new safety signal: dysesthesia (abnormal skin sensations) in 4.4 to 20.9% of participants at the 12 mg dose depending on trial population
At 1 mg, the GIP receptor is roughly 48% engaged and the liver is already burning fat (51% reduction in the MASLD substudy)
Researchers can adjust dosing and duration based on the desired therapeutic effects, target area, severity of condition, and other factors
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