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Types of alpha-lipoic acid supplements Outside of standard racemic ALA and purified R-ALA which weve covered above youll also find a few other supplement formats designed to enhance absorption, reduce side effects, or combine ingredients for synergistic effects: Encapsulated or time-release ALA These formulations gradually release ALA over several hours rather than all at once.62 Slower absorption may reduce gastrointestinal side effects like nausea or reflux and help maintain more stable blood levels throughout the day

Chronic kidney disease (CKD) is the most common concurrent illness, estimated to affect up to one-third of patients (Carney et al, 2016)

The gut microbiota and CVDs The human gut is colonized by approximately 100 trillion microorganismsincluding beneficial bacteria, neutral bacteria, and pathogenic bacteriawhich cooperate to maintain homeostasis of the gut microecology ( Bacteroidetes and Firmicutes account for approximately 90% of the total gut microbial abundance, followed by Proteobacteria (5-10%), Actinobacteria (3%), and Verrucomicrobia ( Intestinal dysbiosis refers to imbalance in the composition and abundance of gut microbiota and is associated with numerous diseases and phenotypes ( Supplementary Table 1 )