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Considering the positive impact of Nrf2 in ameliorating oxidative stress, a number of bioactive components that exert protective effect against APAP-associated hepatotoxicity have been identified and reported, including caffeic acid that activates the Keap1-Nrf2 antioxidant defense system (Pang et al., 2016), carnosic acid that promotes nuclear translocation of Nrf2 (Guo et al., 2016), and esculentoside A that activates Nrf2 via AMP-activated kinase/Akt/glycogen synthase kinase 3 pathway (Wang et al., 2016)

In nave animals, CYP2E1 is present predominantly in evolutionarily older areas of the allocortex, such as the olfactory bulbs, olfactory cortex, hippocampus, cerebellum and the brainstem (117)

By pre-adsorbing IgG on the surface of liposome nanomedicines, a special protein corona was formed

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