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Description
Because high xCT levels are associated with poor prognosis in a number of cancer types, including GBM 66 and triple-negative breast cancer 67 , the xCT transporter has been suggested as a therapeutic target for cancer 6769
Hing B, Braun P, Cordner ZA, Ewald ER, Moody L, McKane M, Willour VL, Tamashiro KL, Potash JB
In the context of liver cancer, artemisinin has been demonstrated to reduce the protein expression of actin filament associated protein 1-like 2 (AFAP1L2) and reverses sorafenib resistance in specific liver cancer cell lines (Hep G2, Hep3B, MHCC-97 H, and Huh-7) [118]
doi: 10.1172/JCI115286
