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R., Aigner E., Dallos T., Sahinbegovic E., Krenn V., Thaler C., et al

In combination with histone modifications, DNA methylation has a fundamental role in modulating gene expression in germ cells by inhibiting the binding of transcription factors to enhancers or by recruiting the binding of proteins that facilitate the deacetylation or methylation of histones, thereby stabilizing the nucleosomes (142)

Lauretani F, Testa C, Salvi M, Zucchini I, Giallauria F, Maggio M (2023) Clinical evaluation of sleep disorders in Parkinsons disease

Notably, INCB054329, a BET domain inhibitor, is undergoing clinical trials for the treatment of Ewings sarcoma and advanced cancers (NCT03514407 and NCT02431260)
