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ADL: activities of daily living, CGI: clinical global impressions scale, LARGO: lasting effect in adjunct therapy with rasagiline given once daily, OFF: poor symptom response, ON: good symptom reponse, PD-QUALIF: parkinson's disease quality of life, PRESTO: Parkinson's rasagiline efficacy and safety in the treatment of OFF, TEMPO: trial of etanercept and methotrexate with radiographic patient outcomes, UPDRS-ADL: unified parkinson's disease rating scale-activities of daily living