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The system that removes these toxic reactive oxygen species includes a host of enzymes including four enzymes Glutathione peroxidase (GPX)- GPX detoxifies peroxides with glutathione acting as an electron donor in the reduction reaction, producing glutathione disulfide as an end product

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however, deletion of both MSR and CD36 greatly reduces lesion complexity and vulnerable plaques, the most critical aspect of lesion development (347)