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Nasal deliverys proximity to the olfactory nerve pathway provides a potential direct CNS access route that has generated specific research interest in intranasal neuropeptide delivery studies making the nasal spray format a distinct and research relevant presentation compared to injectable DSIP preparations for protocols examining central neuropeptide activity

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Figure 4 Figure 5 Metabolic pathway enrichment analysis To further explore the biological role of identified metabolites, we performed the pathway enrichment analysis based on the KEGG metabolic network ( Figure 6A )