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Description
doi: 10.1172/JCI43304
Replicative senescence is secondary to telomere shortening as the cell undergoes repeated divisions
CQ can form a stable complex with Cu(II), namely CuCQ, which exhibits potent cytotoxicity in human cancer cell lines (Khan et al., 2020
This specific property has become the focus of numerous research strategies, such as the development of senolytic agents like FOXO4-DRI, which selectively disrupt the FOXO4p53 interaction, thereby enabling the targeted elimination of dysfunctional cells
