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AA147 covalently modifies KEAP1 to promote NRF2 activation in HT22 cells NRF2 activity is primarily regulated through its interaction with the redox sensor E3 ligase protein KEAP1 ( Fig
Science 334 , 678683 (2011)
Accordingly, loss of SIRT4 enhances glutamine-dependent proliferation and genomic instability, which simultaneously contribute to tumorigenesis 151
B Skull Base 85, 227233
