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Description
In addition to the KEAP1-dependent pathway, NRF2 degradation is regulated by an additional -TrCPdependent degradation pathway, via NRF2 phosphorylation by GSK3 in a PI3K-dependent manner (Hayes et al., 2015)
These findings underscore the therapeutic potential of natural compounds as promising alternatives or complementary treatments for AD
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The method of embodiment 114, wherein the composition comprises from about 14 wt % to about 18 wt % poloxamer 407
