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It also suppresses NF-B and JAK2/STAT3 signaling, reducing IL-6 and other pro-inflammatory cytokines (Zhu et al., 2024)

Several studies have demonstrated that maternal nutrition during pregnancy has significant phenotypic, molecular, and metabolic effects, with both short and long-term consequences for the offspring [5, 10,11,12]

Overexpression of SIRT3 prevents CypD acetylation, which limits the opening of MPTP and mitigates necroptosis [72]
This alteration might enhance the capacity of cells to eliminate mitochondrial reactive oxygen species (ROS) accumulated due to aerobic oxidation in sepsis (16)
