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According to the criteria adopted in these guidelines, subjects with FH and without other major risk factors are considered high-risk patients, while those with FH and ASCVD or other major risk factors are considered very high-risk patients, which implies a recommendation to achieve specific treatment goals ( 10 years, the target LDL-C concentration should be 500 mg/dl) and an increased rate of atherosclerosis development (tendon and skin xanthomata below 10 years of age) and significantly increased cardiovascular risk [9, 265]

doi:10.1177/1759720x231182894

Thus, our data demonstrate that PTCH also controls intracellular cholesterol levels in C

& Barreto, G