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In erythrocytes, if the PPP does not function, then the (RBC) oxidative stress will lead to lysis , anemia
Fertil Steril 110(7):12981310 Bergan-Roller HE, Sheridan MA (2018) The growth hormone signaling system: insights into coordinating the anabolic and catabolic actions of growth hormone
GSR activity is also NADPH-dependent, connecting glutathione recycling to the pentose phosphate pathway (G6PD activity) and the NADPH-generating capacity of the cell
It is speculated that HCV, by damaging liver, may promote systemic oxidative stress in part by disruption of GSH export
