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Additionally, iron is involved in maintaining the antioxidant balance of the retina, helping to eliminate free radicals and protect the retina from oxidative damage ( 2.2 Execution 2.2.1 GPX4 inactivation The glutathione peroxidase (GPX) family comprises various isoforms, including GPX1 through GPX8, with GPX4 playing a particularly crucial role in the context of ferroptosis ( Figure 3 ) (31)

Effects of HT and exogenous GSH on gene expression related to photosynthesis and antioxidant enzymes The expression level of all the Calvin cycle enzyme genes investigated here were significantly up-regulated during the HT stress under the HT+GSH treatment compared to the HT treatment (except for fructose-1,6-bisphosphatase ( FBPase ) for which the increase was not significant) (Fig

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