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In vitamin B12 deficiency, there is an over-production of both serotonin and dopamine and so one would expect that the number of receptors that can respond to stimulus is gradually reduced

Unlike a long-acting compound that commits a subject to a week-long effect, the short 5-Amino-1MQ half life allows for more dynamic adjustments to the protocol

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Tolerance and physical dependence may develop, and withdrawal symptoms (fatigue, depression) can follow abrupt cessation after high-dose or prolonged use