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Three to four weeks People with good absorption may still experience benefits, though many improvements linked to deficiency settle down sooner

It's possible that lower doses of each medication might be sufficient when used together, potentially mitigating some of the side effects while maintaining efficacy

The first 2 weeks might bring dramatic relief followed by a period where progress seems to stall

In UK clinical practice the standard injectable diluent is Water for Injections BP, and bacteriostatic water with benzyl alcohol is generally treated as a sterile supply rather than a medicine in its own right unless it is licensed for a specific indication