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These insights have motivated the exploration of alternative strategies that preserve LNP stability and delivery efficiency while minimizing immunogenicity

Huang, P
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Density plot showing decreased abundance of PS and increased abundance of PC-1 for primitive compared to committed phenotype(n = 96 patients)
Chuquet et al., According to this hypothesis, neurons meet their high energetic requirements by utilizing astrocyte-derived lactate (produced from extracellular glucose or glycogen pools), which can be oxidized in the TCA cycle following its conversion to pyruvate
