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Disruption of protein homeostasis is recognized as a hallmark of aging [70], and previous studies have shown that impaired ovarian angiogenesis and vascular remodeling contribute to inadequate follicular development and ovarian aging [71]

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A complete discussion of epidemiological methods is beyond the scope of this article and can be found elsewhere (Reference Prentice and Huang100,Reference Almirall, McCaffrey and Ramchand103Reference Fairchild and McDaniel106)