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In the SCI model, significant expression was observed in the hippocampus and amygdala in the chronic phase at 12 weeks after injury and in the thalamus in the acute (4 days and 2 weeks after injury) and chronic (12 weeks after injury) phases (Figure 6A

Among all the regulatory post-translational modifications, FOXO3 also undergoes lysine methylation mediated by Set7/9

Additionally, the residues VAL294, TRP286, and TYR341 exhibited hydrophobic interactions with the docked compound

Following chronic (6 week) feeding with an ethanol-containing liquid diet, the Gclm KO mice were unexpectedly found to be protected against steatosis despite showing increased oxidative stress (as reflected in elevated levels of CYP2E1 and protein carbonyls)