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The difference between the effects of both QIs on the cell viability ( Figure 2 ) and caspase 3 activation ( Figure 4 ) suggests that upon GSH depletion, the decrease in cell viability is not only apoptosis dependent but also most likely depends other cell death pathways, such as necrosis ( IC 50 values of QIs under GSH-depleted conditions were around 20 M ( Figure 2 ), which is higher than the plasma concentrations of AQ and DEAQ found in patients, normally in nanomolar to micromolar ranges (Laurent et al., 1993

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J Biol Chem 269: 1284612851 [PubMed] [Google Scholar] Boon E.M., van der Neut R., van de Wetering M., Clevers H., Pals S.T

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Ice, Heat, and NSAIDs for Different Pain Stages Acute phase (first 48-72 hours): Ice is your primary tool for reducing inflammation and providing numbing relief

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