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Patients should be reviewed 812 weeks after commencing treatment to assess: Symptomatic improvement, particularly resolution of fatigue and neurological symptoms Haematological response (normalisation of haemoglobin and mean cell volume) Reticulocyte count typically rises within one week, indicating bone marrow response Repeat serum B12 testing is generally not useful after starting parenteral therapy, as levels remain elevated for months

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Timothy Piatkowski, a National Health and Medical Research Council emerging leadership fellow from the school of public health at the University of Queensland, Australia, tells us that the synthetic peptide trend is comparable to the rise of GLP-1 weight loss drugs as seen in the case of the unapproved triple agonist retatrutide

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