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Int J Pharm Pharm Sci 4(4):544547 Caruntu S et al (2020) Thuja occidentalis L

In fact, because the RFC pathway is less efficient, studies use high doses of leucovorin to ensure enough folate reaches the brain

J Am Geriatr Soc 2020;68(3):609613

The HO 2 form is particularly crucial as it can easily traverse the phospholipid bilayer compared to the charged form (O 2 )
