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However, for more severe endothelial dysfunction, chronic venous insufficiency, or significant cognitive impairment, studies frequently employ doses of 150 mg to 200 mg per day, typically divided into two doses (e.g., 100 mg in the morning and 100 mg in the evening)
The proto-oncometabolite fumarate binds glutathione to amplify ROS-dependent signaling
However, at higher doses, it can act as a potent hepatotoxin, and cause cell necrosis (McGill et al., 2013) and acute liver failure (Lee, 2004)
