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Some researchers find the larger injection volumes less comfortable, especially for daily protocols, though retatrutide is administered weekly which makes this less of a concern

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Nature Reviews Endocrinology: The effects of growth hormone on adipose tissue: old observations, new mechanisms Multidisciplinary Digital Publishing Institute: Central Regulation of Metabolism by Growth Hormone Medical Anti-Aging: Sermorelin Medical Evidence Journal of Anti-Aging Medicine: Growth Hormone Releasing Hormone Treatment in Normal Aging Translational Andrology and Urology: Beyond the androgen receptor: the role of growth hormone secretagogues in the modern management of body composition in hypogonadal males Springer Nature Link: Effects of growth hormone therapy on bone density and fracture risk in age-related osteoporosis in the absence of growth hormone deficiency: a systematic review and meta-analysis