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When TLR9 is engaged, it initiates a signaling cascade that activates NF-B and IRAK, leading to the production of chemokines and inflammatory cytokines (Nigar and Shimosato, 2019)
382 By inducing a feed-forward loop involving alternative activation of microglial neuroinflammation, human UC-MSCs produce a sustained neuroprotective effect, thereby ameliorating disease pathophysiology and reversing the cognitive decline associated with A deposition in AD model mice

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Cells 10(9), 2021