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Specifically, one study found that when leaky Madin-Darby canine kidney type II cells were treated with LA, tight junction proteins, including occludin and claudin-3, had less intracellular distribution (and concurrently more membrane expression), whereas actin was more associated with intercellular junctions (25)

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CoQ 10 in Patients with Statin-Associated Myopathy The mechanisms involved in statin-associated myopathy are still unclear, but presumably involve an increase in intracellular lipid production and lipid myopathy and myocellular phytosterols, decrease in sarcolemmal cholesterol, reduction in mitochondrial CoQ 10 and in small guanosine triphosphate-binding proteins [48]