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have shown that acceptance interventions are effective in reducing kinesiophobia and improving performance-related physical functioning in individuals with comorbid obesity, as they can facilitate adherence to physical activity and promote weight loss in this highly comorbid clinical condition [102]

PTEN dephosphorylates PIP3, and thus inhibits PI3Ks activity to phosphorylate PIP2 to produce PIP3, resulting in inhibition of Akt
