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The research on PND and gut microbiota dysbiosis is getting more and more advanced, but there is a lack of research on gut microbiota alterations and postoperative cognitive changes after surgery and anesthesia, and more basic and clinical research is needed in the future to focus on the role of specific gut microbiome and specific targets of gut microbiota and provide new approaches for the treatment of PND

10.1016/j.biopha.2020.110660 262 WangP.ZhuP.YuC.WuJ

one such mechanism includes increased intestinal permeability or the leaky gut, which is very prevalent in the case of PD

So, to pull the skin away from anything dangerous to inject near the area, Im going to have to get creative