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Role of poly [ADP-ribose] polymerase 1 in activating the kirstenras (KRAS) gene in response to oxidative stress

It may be of importance in infants when milk formulas and gruels are the main dietary source of folate
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By contrast, in p21 KO cells, nutlin-3 treatment resulted in the differential expression of even more genes than observed in Control cells, consistent with the notion that p21 is itself an important transcriptional regulator (Fig 3A) (Delavaine & La Thangue, 1999