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It provides descriptions of the statutory provisions that are addressed, identifies the proposed policies, and presents rationales for our decisions and, where relevant, alternatives that were considered

The negative effect may be attributed to the fact that VEGF also has the potential to stimulate the expression of matrix metalloproteinases (MMPs) and inhibit the expression of tissue inhibitors of metalloproteinases (TIMPs) in endothelial cells and fibroblasts (Pufe et al., 2005