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They found that fibroblast-like PMCs had more mtROS and less membrane potential than epithelial-like PMCs

The most studied mechanisms include: upregulation of growth hormone receptors in fibroblasts (increasing sensitivity to healing signals), activation of the FAK-paxillin pathway (promoting cell adhesion and migration), modulation of the nitric oxide system through Src-Caveolin-1-eNOS phosphorylation (enhancing vascular function), and dual activation of the Egr-1/NAB2 gene loop (promoting organized, non-chaotic blood vessel growth)

The two major gut bacteria with significantly increased abundance, Blautia and Dorea , were shown to correlate positively with estrogen levels in patients with stage 3/4 endometriosis ( 2.1.3 Progesterone and the progesterone receptor (PR) Ovarian-derived progesterone regulates the periodic decidualization of endometrial stromal cells and facilitates the formation of an endometrial microenvironment that promotes blastocyst receptivity and embryo implantation

Tabe Y, Konopleva M, Kondo Y, Contractor R, Jin L, Ruvolo V, Tsutsumi-Ishii Y, Miyake K, Miyake N, Ohsaka A, Nagaoka I, Issa JP, Andreeff M