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Their peptide, FOXO4-DRI, was selected from screening a small list of peptides derived from both FH and CR3 domains of FOXO4 and it was illustrated to bind TP53 [17]

HIF-1 activated pyruvate dehydrogenase kinase 1 (PDK1), an inhibitor of pyruvate dehydrogenase (PDH) needed for pyruvate to form acetyl-CoA, thus blocking the entry into the Krebs cycle

doi: 10.1016/j.tins.2021.07.004

A very interesting study of 304 subjects with ICD indicated that patients on statins had a significantly lower level of derivatives of ROS (DROMs) (a measure of lipid peroxides), and the DROMs and statins were strongly associated with ICD events [86]