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Overall, bromelain appears to exert its biological effects through a multi-target mechanism involving suppression of pro-inflammatory pathways (NF-B, MAPK), activation of antioxidant responses (Nrf2), modulation of immune signaling, and proteolytic regulation of key molecular targets

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Couto N, Wood J, Barber J (2016) The role of glutathione reductase and related enzymes on cellular redox homoeostasis network

Recent findings have revealed CCL11 to be a critical biomarker of long-term brain damage in a mouse model of mild COVID-19 33