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202,203 Ferroptosis can occur by targeting two main pathways, the extrinsic or transporter (e.g., SLC7A11, SLC38A1, NOXs and TFRC)-dependent pathway and the intrinsic or enzyme (e.g., ACSL4, ALOXs, GPX4, POR, GCH1, NOS and AIFM2)-regulated pathway

Hepatology 65 , 18751890 (2017)

Notably, there is no direct interaction between the two LepR ECDs, suggesting that receptor dimerization is primarily ligand-dependent, as has been observed for other class 1 cytokine receptors 26

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