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In order to investigate if the substrate binding protein of Gsi (GsiB) transfers GSH to Opp or vice versa (OppA to Gsi), we generated GSH-deficient cells lacking either OppA and GsiC or GsiB and OppC and expressed Grx1-roGFP2 in the resulting gshA gsiB oppC and gshA oppA gsiC triple mutants (see Figure 7 A for a schematic overview)

It is worth noting that there may be a paradox in the NRF2based antioxidant therapy, such as in the cases of aging and cancer

Stabler, Identification and quantitation of cobalamin and cobalamin analogues in human feces , The American Journal of Clinical Nutrition , vol

Long-term ethanol feeding enhances susceptibility of the liver to orally administered lipopolysaccharides in rats