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1 Introduction Cancer, an increasingly prevalent disease internationally, has become one of the principal causes of morbidity and death globally, with serious economic costs to society

Under normal conditions, NRF2 remains inactive in the cytoplasm, bound to the KEAP1 protein and cullin 3, which promote its degradation via ubiquitination

The market volume for maleic anhydride was estimated to have reached 1,807,000 tons in 2007, which is much larger than the estimated volumes of other four-carbon dicarboxylic acids, such as succinic acid and fumaric acid (270,000 and 90,000 tons per year, respectively) 11

BET inhibitors alter the pro-inflammatory phenotypes of mononuclear phagocytes and impair the recruitment of dendritic cells in vitro