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& Kochenderfer, J

To maintain systemic copper homeostasis within physiological limits, cells employ a complex regulatory network of copper enzymes, molecular chaperones, and membrane transport proteins, which collaboratively regulate copper uptake, efflux, and utilization ( The absorption of dietary copper predominantly occurs in the small intestine and duodenum, primarily mediated by the copper transport protein 1 (CTR1), also known as solute carrier family 31 member 1 (SLC31A1), located on the apical side of intestinal epithelial cells (125)

Blue Copper Proteins: a rigid machine for efficient electron transfer, a flexible device for metal uptake

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