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GHK-Cu is a natural tripeptide that, in human plasma, can be found at a concentration of 200 ng/ml at the age of 20 years but drops to around 80 ng/ml by the age of 60 years [34]

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Growth hormone-releasing hormone and the incretin hormones such as GLP-I and GIP belong to the same class of the structurally related hormones that activate class B GPCRs