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282 Pertaining to microglia/macrophages, lactate and histone lactylation promote the conversion of macrophages to M2-type tumor-associated macrophages (TAM), while TAM enhances the transcription of M2-like genes hypoxia-inducible factor 2 (HIF-2), ARG1, and VEGF

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The high homocysteine level in LA most likely reflects its proatherogenic role in the pathogenesis of stroke, and may also explain the increased levels of cysteine and GSH in plasma, since a significant part of homocysteine is converted to cysteine, and the latter, in turn, is required for the formation of GSH

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